Exposure to prenatal stressors can increase the offspring’s disease susceptibility. For example, near the end of World War II, the blockade and disruption of food transport to the Western Netherlands caused one of the worst famines (also called the Dutch Hunger Winter) recorded in history. Children born around that time were reported to have increased susceptibility to chronic diseases. These effects, in fact, were persistent beyond one generation. In this project, we will investigate how stress exposure during different periods of pregnancy affects disease susceptibility in the offspring. We will use state-of-the-art technologies of neurorecording and neuromodulation in mice to investigate how different brain centers of the pregnant female and the developing fetus respond to stressors. We will analyze how these brain centers communicate with the immune and cardiovascular systems of the mother and fetus and how this ultimately induces long-lasting changes in the offspring, potentially making them more prone to developing disease later in life. We have established a comprehensive toolbox to interfere with brain-body communication axes at multiple levels. This allows us to untangle the complex interplay between the two distinct, yet closely linked, brain-immune-vascular networks of mother and unborn child. The goal is to develop novel therapeutic approaches to reduce, if not reverse, the adverse effects of prenatal stress on the offspring’s health.